JNNP Podcast

Pathophysiology of functional neurological disorder

Despite the prevalence of the disease, neurologists and psychiatrists can be wary of treating patients with functional neurological disorder (FND). Assistant Professor David Perez (Massachusetts General Hospital, USA) discusses how FND sits between neurological and psychiatric disciplines, the relationship between poor health status and affective symptoms, and associations with grey matter volumetric profiles. Read more here: http://jnnp.bmj.com/content/88/12/1052.

Is methamphetamine use linked to stroke in young adults?

Is methamphetamine use linked to strokes in young adults? Important clinical implications discussed by Dr. Julia Lappin (University of New South Wales) in this month’s JNNP podcast.
http://jnnp.bmj.com/content/88/12/1079

Cerebral Amyloid Angiopathy: New Insights For Clinical Practice

Cerebral amyloid angiopathy (CAA) has been gaining attention over the past few years, thanks to increased research in the field. Professor David Werring (UCL Institute of Neurology, Queens Square, London) discusses the recent advances in biomarkers analysis, as well as providing an overview of the clinical spectrum of CAA. Read the full paper here: http://jnnp.bmj.com/content/early/2017/08/26/jnnp-2016-314697

Cortical Influences in ALS

Professor Emeritus Andrew Eisen (University of British Columbia, Canada) discusses the theory of corticofugal primary in amyotrophic lateral sclerosis. ALS can be viewed as a primarily human disorder mediated by corticomotorneuronal pathways, originating in the cerebral cortex. Read the full paper here: http://jnnp.bmj.com/content/88/11/917.

Intravenous immunoglobulin in CIDP

Can IViG be used as a longer term maintenance therapy for CIDP patients? JNNP Associate Editor, Professor Satoshi Kuwabara (Chiba University Hospital, Japan) joins us for this podcast, discussing recent trial results and their implications for patient care. Read the full paper here: http://jnnp.bmj.com/content/88/10/832

Complex inherited neuropathies: a new approach to diagnosis?

Professor Mary Reilly (Institute of Neurology, Queens Square, London) discusses how complex inherited neuropathies can be a daunting diagnosis for clinicians. However, through exciting advances in next generation sequencing and knowledge of distinct syndromic categories, a new diagnostic approach emerges. Her review and her interview provide excellent over of this new approach, and how it may serve as a resource for clinicians. Link to paper here: http://dx.doi.org/10.1136/jnnp-2016-313960.

Cerebellum and neurodegeneration; autoantibodies and psychological development in children

The September 2017's JNNP podcast is a double episode.
The first conversation is with Professor Michael Hornberger from the Norwich Medical School, University of East Anglia, UK. The cerebellum is often overlooked when looking at neurodegenerative diseases, a practice which Professor Hornberger and his team are challenging. Their recent JNNP paper looks at patterns of grey matter atrophy in the cerebellum across neurodegenerative diseases. What they found may surprise some listeners.
Read the paper here: http://jnnp.bmj.com/content/88/9/780.
Elizabeth also speaks with Dr Ester Coutinho from the Nuffield Department of Clinical Neurosciences, University of Oxford, UK. Dr Coutinho & colleagues have been looking into maternal transfer of autoantibodies during pregnancy. In particular, their research has focused on antibodies which may be linked to disorders of psychological development in children. Read the paper here: http://jnnp.bmj.com/content/88/9/718.

Time Matters - part 2: how the real costs of multiple sclerosis are being concealed

“Take a comprehensive economic approach to evaluating treatment cost-effectiveness in MS”. Jacqueline Palace (Consultant Neurologist, Nuffield Department of Clinical Neurosciences, University of Oxford) and Ruth Geraldes (Neurologist, Department of Clinical Neurosciences, University of Oxford) examine the economic burden of multiple sclerosis, which was debated at the international roundtable “Time Matters in MS”, organised by the BMJ and the JNNP on World MS Day 2017, in Lisbon.
Read more, watch the videos and access all the information about the event on the JNNP's website special page: jnnp.bmj.com/pages/time-matters-in-ms/.
“Time Matters in preventing disabilities from MS” was supported by an unrestricted educational grant from F. Hoffmann-La Roche and Roche Farmacêutica e Química.

Survival and cause of death in Multiple Sclerosis

There has been an increase in life expectancies for the general population over the last few decades. A similar trend has also been identified in patients with Multiple Sclerosis (MS). To investigate this trend further, Dr Lunde and colleagues, from the Norwegian Multiple Sclerosis Competence Centre, investigated survival and cause of death in an MS cohort.
Dr Lunde discusses the findings with Elizabeth Highton in the August 2017's JNNP podcast. Download the paper here: http://jnnp.bmj.com/content/88/8/621.

Time Matters - part 1: delay is “expensive” in all aspects of multiple sclerosis

Professor Emeritus Alastair Compston (University of Cambridge) discusses with JNNP’s Publisher Janet O'Flaherty the issues raised by the discussion “Brain health matters in multiple sclerosis” (MS), which was part of the international roundtable “Time Matters in MS”, organised by the BMJ and the JNNP on World MS Day 2017, in Lisbon.
Read more, watch the videos and access all the information about the event on the JNNP's website special page: http://jnnp.bmj.com/pages/time-matters-in-ms/.
“Time Matters in preventing disabilities from MS” was supported by an unrestricted educational grant from F. Hoffmann-La Roche and Roche Farmacêutica e Química.